DMPK4BIOTECH

In vitro ADME 

•     Screening  

-   Solubility  

-   Metabolic stability  

-   Metabolite profiling  

-   Permeability  

-   Protein binding 

•     DDI Profiling  

-   CYP phenotyping  

-   CYP inhibition  

-   CYP induction  

-   Transporter inhibition  

-   Transporter involvement

PK Studies 

•     Rodents/Non-Rodents 

-   IV/PO 

-   Single/rising dose levels 

-   Single/repeat dosing 

•     Bioananlysis (plasma, tissues)

•     PK support for formulation

                                    development 

•     Efficacy studies  

-   PK/PD/E correlations 

•     Human PK prediction 

-   Allometric scaling 

-   In vitro-in vivo extrapolation